Ex: C0006933 C0007102 C0007203 C3175196    or

CUI: C0057916   dienogest 
An orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therapy and as a female contraceptive. Upon oral administration, dienogest binds intracellular progesterone receptors which then translocate to the nucleus where the drug-receptor complex interacts with progesterone response elements, thus altering the expression of target genes. Dienogest reduces the production of estradiol, prevents ovulation and alters the cervical mucus and endometrium. In addition, dienogest appears to suppress the expression of cell cycle regulator cyclin D1. Altogether, this may prevent the growth of endometrial epithelial cells and may reduce symptoms associated with leiomyoma.

rdfs:seeAlso — C0700307 C0028131 C0596067 C0599215 C1706935 C0028609 C0598171 C1518453 C0033306

skos:closeMatch —

skos:exactMatch — C0057916

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