Ex: C0006933 C0007102 C0007203 C3175196    or

CUI: C0533545   gemifloxacin 
A fluoroquinolone antibiotic with antimicrobial property. Gemifloxacin enters bacterial cells by diffusion through integral membrane porin pathway before targeting both DNA gyrase and topoisomerase IV, two enzymes critical for DNA replication and repair. This agent binds to the DNA/DNA-gyrase complex and inhibits the A subunits of the enzyme thereby preventing the bacterial chromosome from rejoining. This interferes with DNA replication and repair processes as well as transcription, and ultimately leads to bacterial cell death. Gemifloxacin targets at both Gram-positive, -negative and atypical human pathogens.

rdfs:seeAlso — C0016330 C0020249 C0206107 C0002520 C0949771 C0001128 C0001129 C0596078 C0007066 C0596260 C1550600 C0034428 C0949665 C1882518

skos:closeMatch —

skos:exactMatch — C0533545 C1320102 C1321744

UMLS Concepts to DBPedia Link Discovery Browser

Enter an UMLS concept-unique-identifier (CUI) or DBPEDIA resource uri to show its rdfs:seeAlso, skos:closeMatch, and skos:exactMatch mapped relations to DBpedia. Alternatively, you can click on a CUI from the sample list to the right to compare our mapping to Wikidata.