CUI ⟾ or DBPEDIA ⟾
Ex: C0006933 C0007102 C0007203 C3175196    or    http://dbpedia.org/resource/Nosebleed    http://dbpedia.org/resource/Leg

CUI: C2001856   carfilzomib 
An epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.

rdfs:seeAlso —
http://dbpedia.org/resource/Benzyl C0005103 C0653785
http://dbpedia.org/resource/Carbonyl C0596258 C0596259 C0682936
http://dbpedia.org/resource/Atomic_orbital C0598359 C0598889 C0684285
http://dbpedia.org/resource/Action_potential C0678838 C3245505 C0001272 C0522221 C1720744 C2249507
http://dbpedia.org/resource/Epoxomicin C0656383
http://dbpedia.org/resource/Amine C0002508 C0596072 C0597565 C0682958 C1879694
http://dbpedia.org/resource/Methyl_group C0596922

skos:closeMatch —

skos:exactMatch —
http://dbpedia.org/resource/Carfilzomib C2001856 C3475268


UMLS Concepts to DBPedia Link Discovery Browser


Enter an UMLS concept-unique-identifier (CUI) or DBPEDIA resource uri to show its rdfs:seeAlso, skos:closeMatch, and skos:exactMatch mapped relations to DBpedia. Alternatively, you can click on a CUI from the sample list to the right to compare our mapping to Wikidata.