Ex: C0006933 C0007102 C0007203 C3175196    or

CUI: C2001856   carfilzomib 
An epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.

rdfs:seeAlso — C0005103 C0653785 C0596258 C0596259 C0682936 C0598359 C0598889 C0684285 C0678838 C3245505 C0001272 C0522221 C1720744 C2249507 C0656383 C0002508 C0596072 C0597565 C0682958 C1879694 C0596922

skos:closeMatch —

skos:exactMatch — C2001856 C3475268

UMLS Concepts to DBPedia Link Discovery Browser

Enter an UMLS concept-unique-identifier (CUI) or DBPEDIA resource uri to show its rdfs:seeAlso, skos:closeMatch, and skos:exactMatch mapped relations to DBpedia. Alternatively, you can click on a CUI from the sample list to the right to compare our mapping to Wikidata.